Hemophilia diseases are anomaly of blood coagulation that appears clinically only in males. Patients with this disease have a decreased or absent serum concentration of antihemophilic globulin and suffer a lifelong tendency for spontaneous hemorrhage.
The most radiographic changes in hemophilia are troubles of recurrent bleeding into the joints. Submucosal bleeding into the wall of the gastrointestinal tract may develop in hemophilia. This most commonly involves the small bowel and produces a short or long segment with regular thickening of folds (picket-fence or stack-of-coins appearance). In the colon, bleeding may produce the thumbprinting pattern of sharply defined fingerlike marginal indentations along the contours of the colon wall.
Abnormal conditions of the urinary tract in hemophilia include intrarenal and perinephric hematomas, calyceal defects resembling papillary necrosis, and global renal enlargement. Obstructive uropathy may be caused by ureteral blood clots or be due to incomplete resorption and subsequent fibrosis of a retroperitoneal hematoma.
Thrombocytopenia is the most common abnormal side of hemostasis resulting in bleeding in the surgical patient. A wide variety of diseases can lead to reduction in the platelet count and purpuric bleeding. Thrombocytopenia may be primary and idiopathic or secondary to such conditions as replacement of the bone marrow by leukemia, metastatic tumor, or fibrous tissue; drug reaction; systemic lupus erythematosus; or congestive splenomegaly due to portal hypertension
The big number of radiographic changes caused by thrombocytopenia primarily involve the gastrointestinal tract. Hemorrhage info the small bowel produces characteristic uniform, regular thickening of small bowel folds in the affected intestinal segment. Splenomegaly is present in patients with thrombocytopenia due to bone marrow failure, portal hypertension, and idiopathic thrombocytopenic purpura. In the last condition, splenectomy is often required to remove this important site of platelet destruction and major source of synthesis of platelet antibodies. Other health articles; mesenteric artery occlusion, keloid forms , bleeding disorders, diseases of the hearth , breast cancer
